A spinal cord neuroprosthesis for locomotor deficits due to Parkinson’s disease

Neuroscientists and neurosurgeons at the EPFL/CHUV/UNIL, Inserm and the University of Bordeaux have designed a neuroprosthetic intended to correct walking disorders associated with Parkinson’s disease. In a study published in Nature Medicine, the scientists set out in detail the process of developing the neuroprosthetic that has allowed a first patient with Parkinson’s to be treated, enabling him to walk comfortably, confidently and without falling.

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Jimmy Ravier
The neurons that restore walking after paralysis

A new study by scientists at the .NeuroRestore research center hasidentified the type of neuron that is activated and remodeled by spinalcord stimulation, allowing patients to stand up, walk and rebuild theirmuscles – thus improving their quality of life. This discovery, made innine patients, marks a fundamental, clinical breakthrough. The study waspublished today in Nature.

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Jimmy Ravier
Principles of gait encoding in the subthalamic nucleus of people with Parkinson’s disease

Most patients with advanced Parkinson's disease develop disturbances of gait and balance, which severely affect their everyday mobility, independence, and quality of life. Using a last generation deep brain stimulation implant able to simultaneously stimulate and record the brain, we identified the neural activity patterns that correlate with normal and pathological gait. These results open new avenues for the development of adaptive neuromodulation therapies that can target gait deficits and prevent falls in real-time.

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Jimmy Ravier
Electronic implant reactivates spinal-cord nerves of a patient with neurodegenerative disease

A patient suffering from a debilitating neurodegenerative disease was able to get up and walk again after being bedridden for over a year, thanks to an innovative system developed by a team of scientists at the NeuroRestore research center headed by Jocelyne Bloch, a neurosurgeon at Lausanne University Hospital (CHUV) and Professor at University of Lausanne UNIL, and Grégoire Courtine, an EPFL professor in neuroscience. Their system includes electronics implanted directly on the spinal cord to reactivate the neurons that regulate blood pressure, thereby preventing the patient from losing consciousness every time she is in an upright position.

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Jimmy Ravier
New treatment helps patients with a spinal cord injury

Spinal cord injuries disrupt the mechanism by which our bodies regulate blood pressure. A team of Swiss and Canadian scientists have developed a treatment that allows patients to regain control of their blood pressure, using targeted electrical spinal-cord stimulation. No medication is required. The team’s findings were published today in Nature.

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Jimmy Ravier
Grégoire Courtine wins the IET A F Harvey Engineering Research Prize

Grégoire Courtine, a neuroscientist and EPFL researcher in Switzerland, has been awarded the IET A F Harvey Engineering Research Prize – the most valuable prize of £350,000 (CHF 420,000) given out by the Institution of Engineering and Technology (IET). Courtine will use the funding to further his research on spinal cord regeneration. Several paraplegics have already regained the use of their legs thanks to his work.

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Jimmy Ravier
NeuroRestore Center: aimed at restoring lost neurological function

The Defitech Foundation has teamed up with EPFL, CHUV and UNIL to widen access to the groundbreaking neurotechnology developed under the 2018 STIMO study, which allowed paraplegic patients to walk again. Their aim is also to develop new neurosurgical treatments for people suffering from Parkinson’s disease or from neurological disorders following a head injury or stroke.

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Jimmy Ravier